SharePoint designer plays a very important role in terms of site
customizations. If it struck somewhere then it will be a big problem.
Would like to share such incident based on the same. By default all
sharepoint sites are blocked in designer in our enviornment, so if any user
wants to customize the site then he has put a seprate request for that
then site will be allowed to open it in sharepoint designer.
What happens exactely: I have allowed site to open in SPD but user was
not able to open and getting access denied. I tried opening the site in SPD
from my side then it opens fine without any issues so one thing was clear
that this is machine specifc. here cache comes into the picture.
1. Close SharePoint Designer.
2. Open My Computer
3. Go to %System Drive%\Documents and Settings\%user%\Local Settings\Application Data\Microsoft\WebSiteCache
4. Just delete all these directories and everything should work when you boot SPD).
5. Restart the SharePoint Designer.
I would be more than happy to help you as well as resolves your issues, Thank you